貨號
產(chǎn)品規(guī)格
售價
備注
BN40721R-100ul
100ul
¥2360.00
交叉反應(yīng):Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用:WB
BN40721R-200ul
200ul
¥3490.00
交叉反應(yīng):Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用:WB
產(chǎn)品描述
英文名稱 | RAR alpha |
中文名稱 | 維甲酸受體RAR α/RAR α抗體 |
別 名 | Acute Promelocytic Leukemia Breakpoint Cluster Region; Acute Promelocytic Leukemia Breakpoint Cluster Region; NR1B1; Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein; Nuclear receptor subfamily 1 group B member 1; Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form; RAR A; RAR alpha; RAR alpha; RAR alpha form; RAR alpha form; RAR; RAR-alpha; RARA; RARA; RARA protein; RARA/PML Fusion Gene; RARA/PML Fusion Gene; RARA_HUMAN; RARalpha; RARalpha1; Retinoic acid receptor alpha; Retinoic acid receptor alpha polypeptide |
研究領(lǐng)域 | 腫瘤 細胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細胞凋亡 激酶和磷酸酶 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
產(chǎn)品應(yīng)用 | WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 51kDa |
細胞定位 | 細胞核 細胞漿 |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human RAR alpha:161-260/462 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
PubMed | PubMed |
產(chǎn)品介紹 | Acute Promelocytic Leukemia Breakpoint Cluster Region; Acute Promelocytic Leukemia Breakpoint Cluster Region; NR1B1; Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein; Nuclear receptor subfamily 1 group B member 1; Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form; RAR A; RAR alpha; RAR alpha; RAR alpha form; RAR alpha form; RAR; RAR-alpha; RARA; RARA; RARA protein; RARA/PML Fusion Gene; RARA/PML Fusion Gene; RARA_HUMAN; RARalpha; RARalpha1; Retinoic acid receptor alpha; Retinoic acid receptor alpha polypeptide Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing MLL5. Mediates retinoic acid-induced granulopoiesis. Subunit: Heterodimer; with RXRA. Binds DNA preferentially as a heterodimer. Interacts with CDK7 By similarity. Interacts with coactivators NCOA3 and NCOA6. Interacts with NCOA7; the interaction requires ligand-binding. Interacts with MLL5. Interacts (via the ligand-binding domain) with PRAME; the interaction is ligand (retinoic acid)-dependent. Interacts with AKT1; the interaction phosphorylates RARA and represses transactivation. Interacts with PRKAR1A; the interaction negatively regulates RARA transcriptional activity. Interacts with NCOR1 and NCOR2. Interacts with PRMT2. Interacts with LRIF1. Interacts with ASXL1 and NCOA1. Subcellular Location: Nucleus. Cytoplasm. Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation. Post-translational modifications: Phosphorylated on serine and threonine residues. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity. Phosphorylation by AKT1 is required for the repressor activity but has no effect on DNA binding, protein stability nor subcellular localization. Phosphorylated by PKA in vitro. This phosphorylation on Ser-219 and Ser-369 is critical for ligand binding, nuclear localization and transcriptional activity in response to FSH signaling. Sumoylated with SUMO2, mainly on Lys-399 which is also required for SENP6 binding. On all-trans retinoic acid (ATRA) binding, a confromational change may occur that allows sumoylation on two additional site, Lys-166 and Lys-171. Probably desumoylated by SENP6. Sumoylation levels determine nuclear localization and regulate ATRA-mediated transcriptional activity. Trimethylation enhances heterodimerization with RXRA and positively modulates the transcriptional activation. Ubiquitinated. DISEASE: Chromosomal aberrations involving RARA are commonly found in acute promyelocytic leukemia. Translocation t(11;17)(q32;q21) with ZBTB16/PLZF; translocation t(15;17)(q21;q21) with PML; translocation t(5;17)(q32;q11) with NPM. The PML-RARA oncoprotein requires both the PML ring structure and coiled-coil domain for both interaction with UBE2I, nuclear microspeckle location and sumoylation. In addition, the coiled-coil domain functions in blocking RA-mediated transactivation and cell differentiation. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: P11416 Gene ID: 5914 Database links: Entrez Gene: 5914 Human Entrez Gene: 19401 Mouse Omim: 180240 Human SwissProt: P10276 Human SwissProt: P11416 Mouse Unigene: 654583 Human Unigene: 439744 Mouse Unigene: 91057 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 類固醇受體(Steroid Receptors) RAR-α在人組織細胞分化過程中具有重要作用,尤其在腫瘤分化的特殊階段起到一定的作用,在造血細胞中,RARα表達豐富。 |
| 国产传媒在线观看 | 少妇丰满的肉体A片视频 | 国产女生尿尿久久 | 亚洲AV秘 无码一区花狩 | 无码欧美熟妇人妻影院欧美潘金莲 | 全免费A级毛片免费看黄瓜视频 | 做爱视频免费在线观看 | 老司机午夜福利视频 | 人人妻人人澡人人dvd | 精品人妻无码中文字幕第一区色戒 | 丰满岳乱妇道伦91麻豆 | 一区二区三区无码在线 | 免费美女无遮挡久久久 | 边洗澡边被躁BD在线看 | 精品少妇做爰无码无码 | 午夜动漫北美少妇子 | 国产黄A片免费观看嫩草影院 | 精品国产人妻挑战黑人 | 77774444色情| 中文字幕日韩精品无码内射 | 国产午夜视频在线看 | 红桃视频乱码一区二区三区 | 肥老熟妇伦子伦456视频 | 国产成人精品久久二区二区三区 | 黄色视频网站在线免费观看 | 久久成年人视频免费 | 妇欲欢公爽公妇精品一区 | 无码国产精品一区二区三 | 农村午夜理伦三级 | 亚洲精品久久久久久久久久久 | 囯产精品久久久久久久久久 | 午夜涩涩视频在线观看 | 亚洲Av日韩Aⅴ高潮潮喷无码 | 精品一区二区三区呻吟声 | 91精品一区二区无套内射 | 欧美成人在线精品在线观看 | 17c.com少妇喷水 | 午夜成人免费电影 | 波多野结衣在线观看一区二区三区 | 伦伦影院午夜理论片痴汉 |