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細(xì)胞角蛋白8單克隆抗體

產(chǎn)品貨號(hào)：

BN41989M
中文名稱：

細(xì)胞角蛋白8單克隆抗體
英文名稱：

Mouse anti-Cytokeratin 8 Monoclonal antibody
品牌：

Biorigin

貨號(hào)

產(chǎn)品規(guī)格

售價(jià)

備注
BN41989M-50ul

50ul

￥1486.00

交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt
BN41989M-100ul

100ul

￥2360.00

交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt

產(chǎn)品描述

英文名稱	Cytokeratin 8
中文名稱	細(xì)胞角蛋白8單克隆抗體
別名	card2; Cardiac autoantigen 2 120kD; CK 8; CK8; CK-8; ck8; Cyk 8; cyk8; CYKER; Cytokeratin endo A; Cytokeratin-8; Cytokeratin8; DreK8; EndoA; k0; CYK8; k2c8; K2C8_HUMAN; k8; Keratin 8; Keratin type ii cytoskeletal 8; Keratin, type II cytoskeletal 8; Keratin-8; Keratin8; KO; Krt 2.8; Krt 8; krt8; KRT-8; MGC118110; MGC174782; MGC53564; MGC85764; sb:cb186; Type-II keratin Kb8.
研究領(lǐng)域	腫瘤細(xì)胞生物信號(hào)轉(zhuǎn)導(dǎo)
抗體來(lái)源	Mouse
克隆類型	Monoclonal
克隆號(hào)	10A8
交叉反應(yīng)	Human, Mouse, Rat,
產(chǎn)品應(yīng)用	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:200-800 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	53kDa
細(xì)胞定位	細(xì)胞核細(xì)胞漿細(xì)胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human CK8:
亞型	IgG
純化方法	affinity purified by Protein G
儲(chǔ) 存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]. Function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Subunit: Heterotetramer of two type I and two type II keratins. KRT8 associates with KRT18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1. Subcellular Location: Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix. Tissue Specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. Post-translational modifications: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. DISEASE: Defects in KRT8 are a cause of cirrhosis (CIRRH) [MIM:215600]. Similarity: Belongs to the intermediate filament family. SWISS: P05787 Gene ID: 3856 Database links: Entrez Gene: 3856 Human Entrez Gene: 16691 Mouse Entrez Gene: 25626 Rat Omim: 148060 Human SwissProt: P05787 Human SwissProt: P11679 Mouse SwissProt: Q10758 Rat Unigene: 533782 Human Unigene: 708445 Human Unigene: 358618 Mouse Unigene: 11083 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 結(jié)構(gòu)蛋白（Structural Proteins）上皮細(xì)胞胞質(zhì)中的骨架蛋白除微絲（肌動(dòng)蛋白）、微管蛋白外，主要是細(xì)胞角蛋白（cytokeratins，CK）。CK8也是上皮細(xì)胞的特征性標(biāo)記物：CK8存在于某些正常腺上皮及其腫瘤，包括許多導(dǎo)管上皮和腺上皮，如結(jié)腸、胃、小腸、氣管的上皮和尿路上皮。CK8主要用于腺癌和導(dǎo)管癌的診斷，鱗狀細(xì)胞癌一般不表達(dá)CK8。