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膜粘連蛋白 Ⅱ重組兔單克隆抗體

產(chǎn)品貨號：

BN42151R
中文名稱：

膜粘連蛋白 Ⅱ重組兔單克隆抗體
英文名稱：

Rabbit anti-Annexin A2 (2F4) Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42151R-50ul

50ul

￥2020.00

交叉反應：Human 推薦應用：WB,IHC-P,IHC-F,ICC,IF
BN42151R-100ul

100ul

￥3240.00

交叉反應：Human 推薦應用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱	Annexin A2 (2F4)
中文名稱	膜粘連蛋白 Ⅱ重組兔單克隆抗體
別名	ANX 2; ANX2; ANX2L4; ANXA2; arylsulfatase B; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide (p36); chromobindin 8; LIP2; Lipocortin II; LPC2; LPC2D; P36; P36 protein; PAP-IV; placental anticoagulant protein IV; Protein I; ANXA2_HUMAN; Annexin II; Annexin-2; Calpactin-1 heavy chain; Chromobindin-8; Placental anticoagulant protein IV.
研究領(lǐng)域	腫瘤心血管細胞生物信號轉(zhuǎn)導細胞凋亡
抗體來源	Rabbit
克隆類型	Monoclonal
克隆號	2F4
交叉反應	Human,
產(chǎn)品應用	WB=1:300-1000 IHC-P=1:200-400 IHC-F=1:200-400 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	36kDa
細胞定位	細胞漿細胞膜細胞外基質(zhì) 分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant Human Annexin A2 : 1-200/339
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
產(chǎn)品介紹	This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Subunit: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF. Interacts with human cytomegalovirus (HCMV). Interacts with COCH. Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. Post-translational modifications: Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated. Similarity: Belongs to the annexin family. Contains 4 annexin repeats. SWISS: P07355 Gene ID: 302 Database links: Entrez Gene: 302 Human Entrez Gene: 12306 Mouse Entrez Gene: 56611 Rat Omim: 151740 Human SwissProt: P07355 Human SwissProt: P07356 Mouse SwissProt: Q07936 Rat Unigene: 511605 Human Unigene: 238343 Mouse Unigene: 90546 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 信號傳導（Signaling Intermediates） Annexin 2是新近發(fā)現(xiàn)的纖維蛋白溶解酶原(PLG)和組織型纖溶蛋白溶解酶原激活物(t-PA)的共受體,是Ca2+介導具有高親和力的磷脂結(jié)合蛋白.其介導血管內(nèi)外纖維蛋白溶解,對保持機體內(nèi)環(huán)境穩(wěn)定具有重要作用. 依賴性膜磷脂結(jié)合蛋白Annexin II調(diào)控異常及有害因子的作用,可導致血栓性疾病和動脈硬化癥鈣依賴性膜磷脂結(jié)合蛋白膜粘連蛋白2異常高表達所引起纖溶亢進,是白血病等惡性腫瘤出血合并癥重要機制之一.鈣依賴性磷脂結(jié)合蛋白對其干預和調(diào)控可能為治療上述病癥提供新思路,為臨床治療開辟新途徑.